FLU NEWS SCAN: CDC flu vaccine advice, antiviral drug effectiveness, intradermal H5N1 vaccine, H5N1 outbreaks in Vietnam

first_imgAug 16, 2012CDC renews its call for flu shots for everyone older than 6 monthsThe US Centers for Disease Control and Prevention today published its official recommendations on influenza vaccination for the 2012-13 flu season, renewing its advice that everyone at least 6 months old should be immunized, an advisory it first issued in 2010. The recommendations, prepared by the Advisory Committee on Immunization Practices (ACIP), were published in the Aug 17 Morbidity and Mortality Weekly Report (MMWR), released today. The document includes a minor adjustment in the recommendation on dosing for children aged 6 months through 8 years: that those who have received two or more doses of seasonal flu vaccine since Jul 1, 2010, need just one dose for this season, but the rest need two doses. Among other things, the document includes recommendations about flu vaccination for people with a history of egg allergy. It also notes that a quadrivalent flu vaccine made by MedImmune, containing two influenza B strains to cover both B lineages, was approved in February but is not expected to be available until the 2013-14 season.Aug 17 MMWR articleJun 20 CIDRAP News story on ACIP recommendationsStudy: Antiviral drugs effective in pandemic, post-pandemic flu periodsAlthough clinical symptoms in those infected with pandemic 2009 H1N1 flu (pH1N1) in Japan in 2010-11 were slightly more severe and peak body temperature was significantly higher in young patients than during the previous year’s pandemic, the effectiveness of neuraminidase inhibitors (NIs) like oseltamivir (Tamiflu) remained high, according to a study today in Influenza and Other Respiratory Viruses. Researchers analyzed clinical symptoms and fever data after the first dose of an NI for 365 patients with pH1N1 in 2009-10 and 388 patients who had either pH1N1, H3N2, or influenza B in 2010-11. They found that peak body temperature were significantly higher for pH1N1 patients younger than 20 years in 2010-11 compared with 2009-10. In addition, the percentage of pH1N1 patients with loss of appetite or fatigue was significantly higher in the later season. The team found the percentage of patients without fever after 48 hours of NI treatment was significantly higher for pH1N1 than for the other two strains, but overall NI effectiveness remained high in both seasons and for all strains.Aug 16 Influenza Other Respi Viruses abstractFDA approves trial of intradermal H5N1 vaccine with adjuvant The US Food and Drug Administration has cleared the way for a phase 1 trial of an intradermal H5N1 flu vaccine containing an adjuvant, which will be the first clinical test of such a product, according to the vaccine’s developers. The announcement was made today by the Infectious Disease Research Institute (IDRI), a Seattle-based nonprofit group, and Medicago, a Quebec-based biopharmaceutical company. The organizations said the testing could lead to a vaccine that could be self-administered in the event of a flu pandemic. “Our idea is to ultimately produce a one-dose vaccine that you could give yourself—imagine a flu vaccine that you can easily administer using a simple, painless microneedle device arriving in your mailbox,” said Darrick Carter, PhD, vice president of IDRI’s Adjuvant Technology Program. The vaccine combines a virus-like particle antigen made by Medicago with IDRI’s Glucopyranosyl Lipid A (GLA) adjuvant. Plans for the trial call for enrolling 100 adults, who will receive the vaccine either intradermally or intramuscularly. The research is funded by the Pentagon’s Defense Advanced Research Projects Agency.Aug 16 IDRI-Medicago press releaseVietnam reports six H5N1 outbreaksVietnam has confirmed six new outbreaks of highly pathogenic H5N1 avian flu in village poultry flocks, leading to the culling of more than 7,000 birds, according to a report filed with the World Organization for Animal Health (OIE) yesterday. Dates of outbreak onset varied from Jul 26 to Aug 11, and all the affected villages are in Nam Dinh province in the northern part of the country. Susceptible flocks ranged from 100 to 3,612 birds, and a total of 7,702 poultry were destroyed to prevent disease spread. The report did not specify how many birds were infected or died from the disease.Aug 15 OIE reportlast_img read more

Last-minute Barcelona defeat 10-man Sevilla

first_imgHowever, Barca fought back with Cesc Fabregas reducing the arrears after 53 minutes and then the talking point was the dismissal of Gary Medel for an apparent headbutt on Fabregas which led to him being red-carded with 18 minutes to go.Barca pressed forward and it was Fabregras who equalised with a minute to go before substitute David Villa got the winner in the fourth minute of injury time.Barca coach Tito Vilanova felt it was right to send off Medel.“If a player goes towards another and hits them in the head then the referee does the right thing to apply the law. That is a red card here or anywhere. It is difficult to referee and easy to make mistakes but not in this case,” he said.Sevilla coach Jose Miguel Gonzalez ‘Michel’, who was sent to the stands in closing stages for complaining too vociferously, refused to get drawn into questions about Medel’s dismissal.“Sometimes things are just crystal clear but still rules are about interpretation and I never talk about referees,” he said.“My players were excellent against an excellent rival. I won’t say it was an unjust result but it was frustrating and leaves a bitter taste in my mouth.”The pressure is now very much on Real Madrid who face Deportivo La Coruna on Sunday before they then go head-to-head with Barcelona in the first El Clasico of the season in the league next weekend.Barca started stronger and Pedro Rodriguez fired over in the opening minutes.Goalkeeper Andres Palop then got down well to stop Lionel Messi inside the area after 13 minutes.Sevilla’s Ivan Rakitic had a tame shot from the edge of the area before, on another breakaway, Trochowski gave the home side the lead.The ball came to him after Javier Mascherano tried to clear the danger and from the left-hand side of the area the Sevilla man slotted the ball into the corner.Straight after the restart Sevilla got their second goal after Sergio Busquets gave the ball away in midfield. Medel found Negredo who clipped the ball over the keeper for a fine finish.Barca went close through Pedro Rodriguez before Fabregas pulled a goal back with a shot from the edge of the area.Medel was controversially dismissed for a headbutt on Fabregas and then, in the closing minutes, it was the former Arsenal man who ran through to beat Palop.There was still time three minutes into injury time for Villa to latch onto a Messi pass for the winner.Malaga maintained their unbeaten start as they cruised to a 4-0 victory over Real Betis with the game turning on an early penalty and the sending off of goalkeeper Casto Espinosa.Casto was red-carded for a foul on Eliseu Pereira and after Joaquin Sanchez converted the penalty, Malaga never looked back.They had a series of chances with Ignacio Camacho hitting the post with a header and then Javier Saviola slotted home the second after 28 minutes following an exchange with Francisco Portillo.Midway through the second half Antonio Amaya put the ball through his own net as he intercepted a Nacho Monreal cross and then Isco Alarcon finished clinically to add to Betis’ misery.Elsewhere Valencia beat Zaragoza 2-0 and Real Sociedad also came out on top 2-0 against Athletic Bilbao.0Shares0000(Visited 1 times, 1 visits today) 0Shares0000MADRID, Spain, September 30 – Barcelona struck twice in the final minutes to complete a controversial fightback as they beat 10-man Sevilla 3-2 to go eleven points clear of bitter rivals Real Madrid.Piotr Trochowski put Sevilla ahead after 26 minutes and when Alvaro Negredo doubled the advantage after the break it looked as though the Andalusians would achieve a double over the top two, having beaten Real a fortnight ago.last_img read more